Portale di studi

SWISS PEAK: Perceptions and Expectations of Academic Knowledge in Swiss Paramedicine: A national survey among paramedics on views, needs and opportunities in the academic development of paramedicine


1. Hypothese / Ziel
Primary Objective:
The main goal of the study is to assess the perceptions, needs, and expectations of Swiss paramedics regarding academization and science in the field of emergency medical services. It aims to investigate whether the (partial) academization of the profession is perceived as an opportunity or a threat and which factors influence these attitudes.

Research Question 1:
Do Paramedics in Switzerland perceive the academization of their profession primarily as an opportunity or as a threat?
Hypothesis: The majority perceives academization as an opportunity.
Alternate hypothesis: The majority perceive academization as a threat.
Method: Data will be collected using a standardized questionnaire employing a Visual Analog Scale (0-100)
Statistical Analysis: Significance testing will be performed using a chi-square test for distribution of frequencies or an independent samples-t-test for mean differences.

Research Question 2:
Does the perception of academization as an opportunity or threat differ between paramedics with an academic degree and those without?
Hypothesis: Respondents with an academic background will be more likely to view academization as an opportunity, whereas those with traditional (non-academic)
training will be more likely to perceive it as a threat.
Alternative-Hypothesis: There is no difference between the groups.
Method: Subgroups will be compared according to their title: paramedics with academic degrees and those without.
Statistical Analysis: Analysis will be conducted using mean comparison methods, such as an independent samples t-test or Mann-Whitney-u-test in case of non-normal
distribution.

Research Question 3 (optional):
Which factors significantly influence the perception of academization as an opportunity or threat among Swiss EMS personnel?
Method: Multiple characteristics will be measured, including age, years of professional experience, level of education and job role. Participants attitudes toward academization will be assessed via questionnaire.
Statistical Analysis: Analysis will be conducted using mean comparison methods, such as an independent samples t-test or Mann-Whitney-u-test in case of non-normal
distribution.

Secondary Objective 1:
Another aim of the study is to identify differences in the perception of academization in paramedicine between paramedics with an academic background and those without such educational background.

Secondary Objective 2:
Additionally, the study seeks to determine the key factors that influence the perception of academization and science in emergency medical services (EMS) as either
opportunity or a threat among Swiss emergency personnel.

Scientific Relevance and Future Potential:
This study aims to contribute to the development of professional strategies, educational, and research initiatives that promote advancement in Swiss EMS. This will help the paramedic community in Switzerland remain competitive on an international level and effectively address evolving healthcare demands.

2. Studiendesign / Prozesse
The study targets all non-medical professionals of emergency medical services in Switzerland. This includes certified paramedics, transport paramedics with a federal
specialist certificate, trainees, dispatchers with emergency medical training, instructors and educators working in Switzerland.
There is no comprehensive directory of all professionals in Swiss emergency medical services, but the SPA membership allows for an estimation of the sample size. The SPA has a total of around 1800 members, and the questionnaires will be primarily distributed via the SPA’s email list.
For a population size of n = 1800, with a confidence level of 95% and a margin of error of 5%, the sample size is n = 317. This correspondents to a survey response rate of
17,61%. Great care was taken from the outset to avoid introducing response biases.
Methods such as forced-decision-choice or the conventional five-point Likert scale were deliberately excluded, as they are considered insufficiently sensitive
to the complexity of participants’ opinions. The survey was designed to solicit the broadest possible range of perspectives. Neutrality and balance were
maintained through a dedicated 'Bias and Neutrality Control' process, in which at least three independent reviewers critically examined the survey items and
provided constructive feedback. Question order was also intentionally structured to further minimize suggestive effects. In preparation for this project, several published and ongoing surveys from German-speaking regions were reviewed. In contrast, SWISS PEAK aims to provide a comprehensive and balanced overview of the current landscape and prospects of the profession, without exerting influence on participants’ views.

Inclusion criteria:
Employment: Individuals currently working in Swiss emergency medical services* (Minimum employment level of 20%).
Professional qualification:
- Certified Paramedic with federal diploma
- Transport Emergency Medical Technician
- Intern/Trainee Certified Paramedic
- Intern/Trainee Emergency Medical Technician
- Educator/Instructor
- Dispatcher
- Manager
- Language: Proficiency in one of the study’s designated languages (German, French or Italian).

*The Principality of Liechtenstein utilizes the Swiss professional qualification in emergency services, meaning that individuals from the Liechtenstein Red Cross are
trained according to Swiss standards. This training takes place in Zürich at the Höhere Fachschule für Rettungsberufe (HFRB).

Exclusion criteria
Individuals with an employment level below 20% in Swiss emergency medical
services.
Other professions:
- Individuals not directly engaged in operational emergency medical services roles, for example, accounting personnel without a direct link to EMS.
Missing or no-consent to participate in the survey.

Informed consent procedure:
Each participant is informed that the participation in the research project is voluntary and that he/she may withdraw from the research project at any time. The participants are informed that he/she can ask any question. Enough time is given to the participant. All participants are given an information before starting the questionnaire and a consent form describing the research project. Participants should carefully read and comprehend the informed consent information
provided. By clicking the “Agree” button, they voluntarily consent to participate in the study. Participants are encouraged to print or save a copy of the consent information for their own records. The consent agreement, indicated by their action of clicking “Agree”, will be documented, and retained electronically as part of the study’s records.

Statistical Analysis
All statistical analyses will be performed using R, SPSS, and Excel. Sample size will be calculated as soon as we get the final mailing-list of the SPA. For example: For a
population size of n = 1800, with a confidence level of 95% and a margin of error of 5%, the sample size is n = 317.

Data and Analysis:
- Descriptive Statistics: Mean, standard deviation, and frequency distributions will be calculated to describe the sample and its characteristics.
- Inferential Statistics: Independent samples t-tests and Mann-Whitney-U tests will be used to analyze data, depending on the distribution. All hypothesis tests will apply with a significance level of p < 0.05.
- Additional Statistical Procedures: Depending on the data and research questions, effect size calculations, confidence intervals, and normality tests
may also be applied. Depending on survey participation and sample size, either a 99% or 95% confidence interval will be calculated, with a constant
margin of error of 5%.

Expected Biases and Mitigation Measures:
- Selection Bias: Since the study relies on voluntary participation, there is potential for selection bias. To mitigate this, we are providing reminders and
encouraging widespread participation through professional networks.
- Non-Response Bias: Participants who do not respond might have different perceptions than those who do. Reminder emails are employed to improve
response rates and mitigate this bias.
- Response Bias: Participants might respond in socially desirable ways. The use of an anonymous survey is meant to reduce this tendency and encourage
honest responses.
- All members of the study team reviewed the questionnaires thoroughly. This process led to various discussions and subsequent adjustments to the
questionnaire.
- The leads of the language regions performed a bias control and neutrality check for all questions.

Withdrawal and Discontinuation:
Regarding the question of whether participants have the option to withdraw their consent retroactively, the following applies:
Since the survey is anonymous and participants are not supposed to provide personal information or identifiers, there is no direct way to identify individual responses. This means that without significant effort or the introduction of additional identification methods, it is not possible to isolate and remove a specific participation after
submission.

Due to the anonymity of the survey, withdrawing consent by participants involves substantial logistical effort and would clearly identify the person, which contradicts the
guarantee of anonymity. In an anonymous survey context, data encryption relates to data security rather than participant identification. A key document linking individual responses to users is not maintained, as it would compromise anonymity.

Content Validity
The questionnaire was reviewed by the study team, consisting of 11 individuals with diverse scientific and paramedic backgrounds. These reviews contributed to the content validity by ensuring that all relevant topics were covered and providing an initial assurance of the clarity and relevance of the questions. Adjustments and valuable discussions were made to ensure general understanding.

Cognitive Validity
A cognitive interview was also conducted with the President of the Swiss Paramedic Association. This involvement of an individual outside the study team advanced the validation process. This approach helped identify and clarify the clarity of the questions and potential misunderstandings.

Criterion Validity
An explicit comparison with already validated instruments for evaluating criterion validity was conducted. Elements from established surveys, such as those from Marcus Blanke's dissertation research on the academization in the German paramedic service, were used to support the findings.

Reliabilty
No comprehensive psychometric analysis has been conducted to confirm the reliability of the questionnaire.

Pilot study
Conducting a pilot study with a sufficiently large and representative sample in the paramedic environment posed significant challenges. The professional burdens on paramedics are characterized by irregular shifts, unpredictable assignments, and high physical and psychological demands. These factors significantly limit the availability and willingness to participate in additional projects like pretests.

From past experience in studies within the paramedic field, frequent reminders are needed to achieve the required sample size. Given these circumstances, there's a high risk of selection bias if the sample is limited to 10 to 20 individuals specifically recruited by the study team. Such a selection could yield skewed results by potentially not adequately reflecting the entire breadth of the target population. Moreover, pretesting before completing the Ethics Advisory Opinion was avoided to ensure that any ethical concerns or necessary adjustments in the questionnaire would not lead to a duplicate execution of any potential pretests. This approach was necessary to conserve resources and minimize the burden on participants. It is crucial to find flexible and time-efficient methods to effectively manage these challenges while ensuring the validity of the survey.

The questionnaire has undergone several important validation steps, considering both content and cognitive validities. However, analyses of reliability, a comprehensive pilot study, and the examination of criterion validity are still pending for the questionnaire to be considered fully validated. The practical implementation of pretests in the paramedic field introduces additional challenges.

Overall Ethical Considerations
A core ethical priority for the research team is the provision of an open and respectful platform for all participants, ensuring that no respondent is coerced into expressing any particular stance. Every voice, regardless of gender, age, educational attainment, experience, or professional role, is given equal weight. Importantly, trainees and students are explicitly included to ensure that perspectives from all stages of professional development are represented.

Recognition is given to the heterogeneity of vocational backgrounds, regional contexts, and levels of experience within the Swiss emergency services. The study
acknowledges possible differences between urban and rural needs and structures, and findings will be contextualized with due regard for regional variation. Participation in the survey is entirely voluntary, with reminder emails issued solely to
achieve the desired sample size. At no time is participation compulsory; this voluntary nature is crucial in upholding participant autonomy and protecting decision-making freedom.

Potential Impact and Equity Considerations
SWISS PEAK seeks to bring national visibility to the needs and aspirations of individuals working in Swiss emergency medical services, providing an evidence base to guide the future development of the profession. The focus is shifted away from deficit-based analyses of workforce shortages, toward need-based analyses that can support improved working conditions and professional advancement for highly skilled paramedical staff.
Findings are intended to support professional associations, educational providers, and policymakers in aligning further training opportunities, career progression avenues, and research possibilities with the actual needs of the workforce. The project’s independence from institutional sponsors contributes to its neutrality and the minimization of conflicts of interest.

Finally, the project advances ethical imperatives of equality of opportunity and social participation, replacing subjective assumptions with quantifiable evidence as the basis for decision-making. It aims to contribute to ongoing professionalization and inclusion within the sector.

Risk-Benefit-Assessment
In conducting the SWISS PEAK research project, an extensive assessment of risks and benefits to participants has been undertaken to ensure ethical standards and participant safety. Given the nature of this study, the risks are minimal and are vastly outweighed by potential benefits.

Risks to Participants:
- Procedural Risks: No procedural Risks.
- Data Security Risks: Minimized Risk.

Minimization and Management of Risks:
- Methodological Precautions: We have avoided methodologies like forced-decision choices and conventional Likert scales that could inadvertently bias responses or cause discomfort to participants. Instead, we employ a broad, neutral design allowing for the comprehensive expression of opinions.
- Ethical Oversight: Participation is entirely voluntary, underscoring the importance of autonomy and freedom in decision-making. Reminder emails are the only method used to encourage participation, ensuring that no coercion occurs.
- Data Protection: We have integrated a transparent data management process that prioritizes confidentiality and anonymity throughout the study, promoting a safe environment for honest and open participation.

Potential Benefits:
- Impact on Future Practices: While there may not be immediate benefits to participants, the findings of this study aim to substantially benefit future paramedical professionals. The research seeks to provide a national platform for sharing insights and understanding the needs of Swiss emergency medical services. This effort supports the ongoing professionalization of the field and aims to address workforce challenges with data-driven solutions.
- Strategic Development: By aligning the analysis with the aspirations and conditions of emergency service personnel, the study can inform policymakers and educational institutions. This alignment helps in developing policies and programs that improve working conditions, offer better career progression, and ensure that training meets real-world needs.

In conclusion, the justified risks associated with this research are minimal and heavily managed, while the potential benefits could be substantial in informing and shaping the future landscape of Swiss paramedicine.

Confidentiality and coding
- Project data will be handled with uttermost discretion and is only accessible to authorized personnel who require the data to fulfil their duties within the scope of the research project.
- Survey data are collected using Findmind, a password-protected platform. Once logged in, the data can be downloaded as CSV or Excel files and imported into the statistical program R.
- Anonymization: The questionnaire is designed such that no personal data is collected that would allow for participant identification. There will be no coding, to ensure the anonymity of the participants.
- Before importing the data into the statistical program, a screening process is performed within Findmind. These processes guarantee error-free and complete datasets. Regular integrity checks and validations throughout the analysis process ensure the high quality of the data.
- Access Controls: Access to the data is restricted to authorized individuals, including the project leadership and selected team members, and is secured by strict password policies. Access rights are based on the "need-to-know" principle.

Long-Term Storage and Access Controls

Storage and Access:
Stored data is regularly reviewed even after the study's completion and is redundantly secured on two separate physical storage media. These media are regularly updated. Access to the data is password-protected and restricted to authorized personnel only.

Duration of Storage:
According to Swiss guidelines for good scientific practice, research data should be stored for at least 10 years after the conclusion of the study.

Backup and Recovery:
Redundant storage media significantly minimize the risk of complete data loss. If a storage medium fails, an immediate copy is made from the functioning medium to ensure data integrity.
By implementing these measures, we ensure that research data remains secure, accessible, and traceable throughout the entire storage period.

Deletion and Destruction of Study Data
After the mandatory storage period of 10 years following the completion of the study, the research data will be securely destroyed from the two separate physical storage media. This process ensures that the data is rendered irretrievable and safeguards participant confidentiality. The secure data destruction will involve several steps:
- Data Overwriting: Data on both storage media will be overwritten using state-of-the-art data sanitation software. This process replaces existing data with random information, making recovery impossible.
- Physical Destruction: Following data overwriting, the storage media themselves will be physically destroyed. This may involve degaussing, shredding, or pulverizing the media to ensure they cannot be reconstructed or accessed in any form.
- Documentation: A detailed record of the destruction process will be maintained, including dates, methods used, and personnel involved. This ensures compliance with data protection regulations and offers transparency.

These measures collectively guarantee that participant data is securely and permanently destroyed, upholding the commitment to data confidentiality and adherence to ethical research standards.

Conflict of Interest
The authors declare no conflicts of interest. There are no political offices or other obligations that could influence the independence of the research.

Independence of Research
The authors conduct their research independently. The statements made and the conclusions drawn in this project are those of the research team and do not necessarily reflect the views or positions of their respective employers or institutions.

Conclusion
In sum, the SWISS PEAK research initiative is conceived as a constructive and respectful scientific contribution to the ongoing dialogue regarding the attitudes and expectations toward science and academization within the Swiss emergency medical services sector.

3. Ergebnis / Endpunkt
Primary Endpoint:
The primary endpoint involves capturing the attitudes of personnel towards academization and science in emergency medical services through a standardized
survey, providing quantifiable data on the extent of their agreement or disagreement with academization and science in paramedicine. This will be measured using a visual analog scale (0 to 100).

Secondary Endpoint 1:
Measurement of different perceptions of academization and science in paramedicine, using mean-values, t-tests, or Mann-Whitney-U-tests to quantify differences in
attitudes between the two groups.

Secondary Endpoint 2:
Collection, analysis, and identification of variables (age, professional experience, educational level, additional tasks) through multivariate analyses that serve as
significant predictors of attitudes towards science and academization in paramedicine.

Scopo dello studio: Strutture e processi

Classificazione: Studio non clinico

Multi-/Monocentrico: Multicentrico

Sede dello studio: National

Durata: 01.04.2025-31.12.2025

Attivo/inattivo: Attivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Felix Brinkmann

Commenti:

Contatto: Felix Brinkmann

Dateien:

ID: 45320

Basec ID:

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Release velocity ImprovemenT with a new Metronome guIding chest COmpressions: The RITMICO simulation study


1. Ipotesi / Obiettivo
Outcomes of out-of-hospital cardiac arrest vary significantly, often due to the quality of cardiopulmonary resuscitation (CPR) provided. Automated real-time feedback devices have been explored to enhance CPR skills, but few devices currently ensure proper chest recoil. This study aimed to assess whether a double-click metronome could improve chest compressions (CC) metrics and particularly CC release velocity (CCRV) during CPR manikin simulation.

2. Design dello studio / Processi
We developed and tested a double-click metronome for CPR, where the first click signals the compression and the second click marks the end of chest release. We performed a multicenter non-blinded, randomized, controlled trial including volunteers with different levels of CPR expertise. Three CC metrics—depth, rate, and CCRV—were measured using an automated external defibrillator equipped with pads for CPR quality analysis.

3. Risultato / Endpoint+
503 volunteers participated in the study, with 54% being male and a mean age of 34 ± 12 years. The median CCRV and CC depth achieved with the double-click metronome were significantly higher compared to the standard metronome (median difference 6 mm/s, IQR-15.2, 28.5, +1.5%, p < 0.001; median difference 0.1 cm, +2.5%, IQR −0.1, 0.4, p < 0.001). The double-click metronome led to significant improvements in CC depth and CCRV across all volunteer categories, with the greater effect observed in first responders and in non-specialized healthcare personnel.

4. Conclusioni:
Compared to a standard metronome, the double-click metronome significantly enhances CPR quality. If further validated in real resuscitations, this new audio prompt could be a valuable tool for integration into devices designed for out-of-hospital cardiac arrest resuscitation, as well as a training tool to improve CPR quality.

Scopo dello studio: Terapia

Classificazione: Studio controllato randomizzato (RCT)

Multi-/Monocentrico: Multicentrico

Sede dello studio: Switzerland:
- Ticino Canton
Italy:
- Pavia
- Palermo
Germany:
- Freiburg
- Grefiswald

Durata: 01.01.2023 - 31.12.2024

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Ticino Cuore Foundation

Commenti: Study completed and pubblished on Resuscitatin Plus 21 (2025) 100867

Contatto: Ruggero Cresta

Dateien: Datei 1

ID: 43407

Basec ID:

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Airway Management Analysis in the Rescue Environment of the Emergency Service Zug (AWARE)


1. Hypothese / Ziel
Airway management is a critical procedure in emergency medicine, especially endotracheal intubation, which can be life-saving. Various techniques, such as video laryngoscopes and conventional laryngoscopes, are used, with success depending on first-pass success. The aim of this retrospective data analysis is to determine the success rate of endotracheal intubation in the first attempt in the Zug Rescue Service between 01/20 and 01/25 with various airway management devices already used in everyday life. The individual complications should secondary with regard to frequency and category as well as possible risk factors. risk factors. The aim is to examine the data on airway management of patients who had to be intubated due to a critical illness (e.g. impaired oxygenation or ventilation, reduced vigilance, cardiovascular arrest, etc.). The data is continuously collected and evaluated by the RDZ as part of quality assurance.

2. Studiendesign / Prozesse
Retroperspective Cohort

Inclusion Criteria:
All adult patients who have had their airway secured by endotracheal intubation by RDZ staff

Exclusion Criteria:
Existence of a documented refusal.
Age < 18 years.

Study Population:
The aim is to examine the data on airway management in the Zug Rescue Service who had to be intubated due to a critical illness (e.g. oxygenation or ventilation disorder, reduced vigilance, cardiovascular arrest, etc.). The data is continuously collected and evaluated by the RDZ as part of quality assurance.

Groups/Cohorts:
videolaryngocopy with bougie (S Guide)
Device: bougie (S Guide) bougie (S Guide) Device: videolaryngoscopy: videolaryngoscopy hyperangulated or Macintosh

conventional laryngoscopy with bougie (S Guide)
Device: bougie (S Guide), bougie (S Guide)

videolaryngoscopy with introducer Device: videolaryngoscopy
videolaryngoscopy hyperangulated or Macintosh

conventional laryngoscopy with introducer: Device videolaryngoscopy hyperangulated or Macintosh

conventional laryngoscopy with introducer: Device conventional laryngoscopy


3. Ergebnis / Endpunkt

Outcome Measure:
- Success rate (first pass success) with the airway management tools already used in the Zug rescue service (Video laryngoscope with Macintosh blade "C-MAC")
- Success rate (first pass success) with the airway management tools already used in the Zug rescue service (hyperangulated video laryngoscope "D-BLADE")
- Success rate (first pass success) with the airway management tools already used in the Zug rescue service (Conventional laryngoscope)
- Success rate (first pass success) with the airway management tools already used in the Zug rescue service (Surgical airway protection)
- Success rate (first pass success) with the airway management tools already used in the Zug rescue service (Bougie/tube introducer)
- Success rate (first pass success) with the airway management tools already used in the Zug rescue service (Stylet/guide rot)

Secondary Outcome Measures:
- Incidence of complications (mechanical damage)
- Incidence of airways retrospectively assessed as definitively difficult (proportion of "definitive difficult airway" to "anticipated difficult airway" and "unanticipated difficult airway")
- Evaluation of operational and patient-related data (Medical/non-medical occupational group)
- Incidence of complications (drop in saturation SpO2 <90%)
- Evaluation of operational and patient-related data (years of clinical experience of the intubator)
- Evaluation of operational and patient-related data (Date, time, day or night shift)
- Evaluation of operational and patient-related data (Reason for initiating resuscitation/DAI)
- Evaluation of operational and patient-related data (Patient demographics (age, gender)

Scopo dello studio: Terapia

Classificazione: Studio di coorte

Multi-/Monocentrico: Multicentrico

Sede dello studio: Emergency Medical Service Canton Zug (CH)

Durata: 01.12.2024 - 01.07.2025

Attivo/inattivo: Attivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Scherr, Benedikt Florian MD

Commenti: Investigators: Benedikt Florian Scherr, MD https://orcid.org/0000-0001-7722-0851 Gian Andrea Cajöri, MD https://orcid.org/0000-0002-1568-0251 Felix Brinkmann, MBA https://orcid.org/0009-0004-7492-3251

Contatto: Felix Brinkmann

Dateien:

ID: 42851

Basec ID:

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Validation of Utstein-Based score to predict return of spontaneous circulation (UB-ROSC) in patients with out-of-hospital cardiac arrest


Background and aims:
The Utstein Based-ROSC (UB-ROSC) score has been developed to predict ROSC in OHCA victims. Aim of the study was to validate the UB-ROSC score using two Utstein-based OHCA registries: the SWiss REgistry of Cardiac Arrest (SWISSRECA) and the Lombardia Cardiac Arrest Registry (Lombardia CARe), northern Italy.

Methods:
Consecutive patients with OHCA of any etiology occurring between January 1st, 2019 and December 31st 2021 were included in this retrospective validation study. UB-ROSC score was computed for each patient and categorized in one of three subgroups: low, medium or high likelihood of ROSC according to the UB-ROSC cut-offs (≤−19; −18 to 12; ≥13). To assess the performance of the UB-ROSC score in this new cohort, we assessed both discrimination and calibration. The score was plotted against the survival to hospital admission.

Results:
A total of 12.577 patients were included in the study. A sustained ROSC was obtained in 2.719 patients (22%). The UB-ROSC model resulted well calibrated and showed a good discrimination (AUC 0.71, 95% CI 0.70–0.72). In the low likelihood subgroup of UB-ROSC, only 10% of patients achieved ROSC, whereas the proportion raised to 36% for a score between −18 and 12 (OR 5.0, 95% CI 2.9–8.6, p < 0.001) and to 85% for a score ≥13 (OR 49.4, 95% CI 14.3–170.6, p < 0.001).

Conclusions:
UB-ROSC score represents a reliable tool to predict ROSC probability in OHCA patients. Its application may help the medical decision-making process, providing a realistic stratification of the probability for ROSC.

Scopo dello studio: Prognosi

Classificazione: Studio di coorte

Multi-/Monocentrico: Multicentrico

Sede dello studio: Switzerland

Durata: 01.01.2019 - 31.12.2021

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Interverband für Rettungswesen IVR-IAS

Commenti: https://www.resuscitationjournal.com/article/S0300-9572(24)00006-6/fulltext

Contatto: Maria Luce Caputo - Department of Cardiology, Cardiocentro Ticino Institute-EOC, Lugano, Switzerland Fondazione Ticino Cuore, Lugano, Switzerland

Dateien:

ID: 38580

Basec ID: -1

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Reporting standard for describing first responder systems, smartphone alerting systems, and AED networks


Standardized reporting of data is crucial for out-of-hospital cardiac arrest (OHCA) research. While the implementation of first responder systems
dispatching volunteers to OHCA is encouraged, there is currently no uniform reporting standard for describing these systems.
A steering committee established a literature search to identify experts in smartphone alerting systems. These international experts were invited to a
conference held in Hinterzarten, Germany, with 40 researchers from 13 countries in attendance. Prior to the conference, participants submitted proposals for parameters to be included in the reporting standard. The conference comprised five workshops covering different aspects of smartphone
alerting systems. Proposed parameters were discussed, clarified, and consensus was achieved using the Nominal Group Technique. Participants
voted in a modified Delphi approach on including each category as a core or supplementary element in the reporting standard. Results were presented, and a writing group developed definitions for all categories and items, which were sent to participants for revision and final voting using
LimeSurvey web-based software.
The resulting reporting standard consists of 68 core items and 21 supplementary items grouped into five topics (first responder system, first responder network, technology/algorithm/strategies, reporting data, and automated external defibrillators (AED)).
This proposed reporting standard generated by an expert opinion group fills the gap in describing first responder systems. Its adoption in future
research will facilitate comparison of systems and research outcomes, enhancing the transfer of scientific findings to clinical practice.

Scopo dello studio: Ricerca sui sistemi sanitari

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Europe
For Switzerland: Interverband für Rettungswesen (IVR-IAS) / Swiss Resuscitation Council (SRC)

Durata:

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: German Resuscitation Council / European Resuscitation Council

Commenti: Please cite this article as: M.P. Mu¨ller, C. Metelmann, K.C. Thies et al., Reporting standard for describing first responder systems, smartphone alerting systems, and AED networks, Resuscitation, https://doi.org/10.1016/j.resuscitation.2023.110087

Contatto: Prof. Michael Müller

Dateien: Datei 1

ID: 38368

Basec ID:

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The impact of COVID-19 pandemic on out-of-hospital cardiac arrest: An individual patient data meta-analysis


Aim: Prior studies have reported increased out-of-hospital cardiac arrests (OHCA) incidence and lower survival during the COVID-19 pandemic. We evaluated how the COVID-19 pandemic affected OHCA incidence, bystander CPR rate and patients’ outcomes, accounting for regional COVID-19 incidence and OHCA characteristics.
Methods: Individual patient data meta-analysis of studies which provided a comparison of OHCA incidence during the first pandemic wave (COVIDperiod) with a reference period of the previous year(s) (pre-COVID period). We computed COVID-19 incidence per 100,000 inhabitants in each of 97 regions per each week and divided it into its quartiles.
Results: We considered a total of 49,882 patients in 10 studies. OHCA incidence increased significantly compared to previous years in regions
where weekly COVID-19 incidence was in the fourth quartile (>136/100,000/week), and patients in these regions had a lower odds of bystander
CPR (OR 0.49, 95%CI 0.29–0.81, p = 0.005). Overall, the COVID-period was associated with an increase in medical etiology (89.2% vs 87.5%,
p < 0.001) and OHCAs at home (74.7% vs 67.4%, p < 0.001), and a decrease in shockable initial rhythm (16.5% vs 20.3%, p < 0.001). The
COVID-period was independently associated with pre-hospital death (OR 1.73, 95%CI 1.55–1.93, p < 0.001) and negatively associated with survival
to hospital admission (OR 0.68, 95%CI 0.64–0.72, p < 0.001) and survival to discharge (OR 0.50, 95%CI 0.46–0.54, p < 0.001).
Conclusions: During the first COVID-19 pandemic wave, there was higher OHCA incidence and lower bystander CPR rate in regions with a highburden of COVID-19. COVID-19 was also associated with a change in patient characteristics and lower survival independently of COVID-19 incidence in the region where OHCA occurred.
Keywords: Out-of-hospital cardiac arrest, COVID-19, SARS-CoV-2, Individual patient data meta-analysis

Scopo dello studio: Terapia

Classificazione: Studio di coorte

Multi-/Monocentrico: Multicentrico

Sede dello studio: Europe

Durata: 2020

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Corresponding author at: Division of Cardiology Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. E-mail address: enrico.baldi@unipv.it (E. Baldi).

Commenti: https://www.resuscitationjournal.com/article/S0300-9572(23)00770-0/fulltext

Contatto: Dr med. Enrico Baldi - Pavia

Dateien: Datei 1

ID: 37950

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A roadmap to building first responder networks: Lessons learned and best practices from Belgium and Switzerland


1. Ipotesi / Obiettivo
Limited bystander assistance and delayed emergency medical service arrival reduce the chances of survival in cardiac arrest victims. Early basic life support through trained first responders (FR) and automatic external defibrillation both improve the outcome. Well-organized FR networks have shown promise, but guidance on effective implementation is lacking. This study evaluates two FR networks, in Belgium and in Switzerland, to identify main advancements in the development of such systems

2. Design dello studio / Processi
Direct comparison is made of the barriers and facilitators in the development of both FR systems from 2006 up until December 2022, and summarized within a roadmap.

3. Risultato / Endpoint+
The Roadmap comprises four integral steps: exploration, installation, initiation, and implementation. Exploration involves understanding the national legislation, engaging with advisory bodies, and establishing local steering committees. The installation phase focuses on FR recruitment, engaging specific professional groups such as firemen, registering public Automated External Defibrillators (AEDs), and requesting feedback. The initiation step includes implementing improvement cycles and fidelity measures. Finally, implementation expands the network, leading to increased survival rates and the integration of these practices into legislation. A significant focus is placed on FR's psychological wellbeing. Moreover, the roadmap highlights the use of efficient geo-mapping to simplify optimal AED placement and automatically assign FRs to tasks

Conclusion
The importance of FR networks for early resuscitation is increasingly recognized and various systems are being developed. Key developmental strategies of the EVapp and Ticino Cuore app system may serve as a roadmap for other systems and implementations within Europe and beyond.

Scopo dello studio: Ricerca sui sistemi sanitari

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ghent University, Ghent, Belgium

Ghent University Hospital, Ghent, Belgium

Emergency Volunteer Application (EVapp) NGO, Belgium

Cardiocentro Ticino Institute, Lugano, Switzerland

Fondazione Ticino Cuore, Lugano, Switzerland

OLVG Hospital, Amsterdam, The Netherlands

Durata: 29.09.2023

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Esther Moens, Eva Degraeuwe, Maria Luce Caputo, Ruggero Cresta, Robin Arys, Nina Van Moorter, Thomas Tackaert, Claudio Benvenuti, Angelo Auricchio, Steven Vercammen

Commenti:

Contatto: marialuce.caputo@eoc.ch

Dateien:

ID: 37027

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Article Impact of the First Swiss Conference on Prehospital Emergency Care and Trauma Research (SPECTRe) on Paramedics’ Intention to Engage in Research: cross-sectional study


Background:
In Switzerland, paramedics lack academic training, meaning they do not receive specialized education in the field of research. Similar to many other European countries, paramedics are seldom included in prehospital research. However, consid-ering the significant gaps in knowledge within prehospital emergency medicine, educating and involving paramedics could markedly enhance prehospital emergency medicine research and decrease knowledge gap in this area.

Objective:
This cross-sectional study aimed to evaluate the impact of the inaugural Swiss Conference on Prehospital Emergency Care and Trauma Research on paramedics’ inclination to participate in prehospital research.

Methods:
A questionnaire was administered using Likert-type scales. All participants (100) were asked to answer a web-based questionnaire after attending the conference.

Results:
Out of 80 responses (80%), 72 were filled by paramedics and therefore included in the analysis. Participants were significantly more willing to engage in prehospital research after attending the conference (40/56, 71.4%) than before (23/56, 41.1%); p<0.001. Among participants already actively involved, 46.7% (7/15) responded that the event had a positive impact on their level of involvement. The results revealed a noteworthily increase in willingness to engage in research.

Conclusions:
A one-day conference solely focused on pre-hospital scientific research serves as a motivating factor for paramedics to partake in research in this domain. Whether this will actually lead to a higher scientific output remains to be seen.

Scopo dello studio: Ricerca sui sistemi sanitari

Classificazione: Studio non clinico

Multi-/Monocentrico: Multicentrico

Sede dello studio: Neuchâtel

Durata: 01.09.2022 - 31.12.2023

Attivo/inattivo: Attivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Multiples auteurs

Commenti:

Contatto: Samuel Zünd - SPS Neuchâtel

Dateien:

ID: 36211

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Out-of-hospital cardiac arrests and mortality in Swiss Cantons with high and low COVID-19 incidence: A nationwide analysis


1. Hypothese / Ziel
Many countries reported an increase of out-of-hospital cardiac arrests (OHCAs) and mortality during the COVID-19 pandemic. However, all these data refer to regional settings and national data are still missing. We aimed to assess the OHCA incidence and population mortality during COVID-19 pandemic in whole Switzerland and in the different regions (Cantons) according to the infection rate.

2. Studiendesign / Prozesse
We considered OHCAs and deaths which occurred in Switzerland after the first diagnosed case of COVID-19 (February 25th) and for the subsequent 65 days and in the same period in 2019. We also compared Cantons with high versus low COVID-19 incidence.

3. Ergebnis / Endpunkt
A 2.4% reduction in OHCA cases was observed in Switzerland. The reduction was particularly high (21.4%) in high-incidence COVID-19 cantons, whilst OHCAs increased by 7.7% in low-incidence COVID-19 cantons. Mortality increased by 8.6% in the entire nation: a 27.8% increase in high-incidence cantons and a slight decrease (0.7%) in low-incidence cantons was observed. The OHCA occurred more frequently at home, CPR and AED use by bystander were less frequent during the pandemic. Conversely, the OHCAs percentage in which a first responder was present, initiated the CPR and used an AED, increased. The outcome of patients in COVID-19 high-incidence cantons was worse compared to low-incidence cantons.

Scopo dello studio: Altro

Classificazione: Studio caso-controllo

Multi-/Monocentrico: Multicentrico

Sede dello studio: SWITZERLAND

Pavia, Italy

Durata: 25.02.2019 - 30.04.2020

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Enrico Baldi

Commenti:

Contatto: Fondazione Ticino cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36719

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Association of Timing of Electrocardiogram Acquisition After Return of Spontaneous Circulation With Coronary Angiography Findings in Patients With Out-of-Hospital Cardiac Arrest


1. Hypothese / Ziel
To assess whether the time from ROSC to ECG acquisition is associated with the diagnostic accuracy of ECG for STEMI.

2. Studiendesign / Prozesse
DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study (the Post- ROSC Electrocardiogram After Cardiac Arrest study) analyzed consecutive patients older than 18 years who were resuscitated from OHCA between January 1, 2015, and December 31, 2018, and were admitted to 1 of the 3 participating centers in Europe (Pavia, Italy; Lugano, Switzerland; and
Vienna, Austria).
EXPOSURE Only patients who underwent coronary angiography during hospitalization and who acquired a post-ROSC ECG before the angiography were enrolled. Patients with a nonmedical cause of OHCAs were excluded.
MAIN OUTCOMES AND MEASURES The primary end point wasf alse-positive ECG findings, defined as the percentage of patients with post-ROSC ECG findings that met STEMI criteria but who did not show obstructive coronary artery disease on angiography that was worthy of percutaneous coronary angioplasty.
3. Ergebnis / Endpunkt
Of586consecutivepatientswhowereadmittedtothe3participatingcenters,370were included in the analysis (287 men [77.6%]; median age, 62 years [interquartile range, 53-70 years]); 121 (32.7%) were enrolled in the participating center in Pavia, Italy; 38 (10.3%) in Lugano, Switzerland; and 211 (57.0%) in Vienna, Austria. The percentage of false-positive ECG findings in the first tertile of ROSC to ECG time (􏰁7 minutes) was significantly higher than that in the second (8-33 minutes) and third (>33 minutes) tertiles: 18.5% in the first tertile vs 7.2% in the second (odds ratio [OR], 0.34; 95% CI, 0.13-0.87; P = .02) and 5.8% in the third (OR, 0.27; 95% CI, 0.15-0.47; P 33 minutes: OR, 0.26; 95% CI, 0.14-0.47; P 33 minutes: OR, 0.27; 95% CI, 0.15-0.46; P 33 minutes: OR, 0.28; 95% CI, 0.15-0.52; P 33
minutes: OR, 0.27; 95% CI, 0.15-0.48; P 33 minutes: OR, 0.29; 95% CI, 0.15-0.55; P < .001), epinephrine administered (􏰁7 minutes: reference; 8-33 minutes: OR, 0.35; 95% CI, 0.13-0.98;
P = .045; >33 minutes: OR, 0.27; 95% CI, 0.16-0.48; P 33 minutes: OR, 0.26; 95% CI, 0.15- 0.46; P 33 minutes: OR, 0.27; 95% CI, 0.16-0.48; P < .001) in bivariable analyses.

Scopo dello studio: Diagnosi

Classificazione: Studio di coorte

Multi-/Monocentrico: Multicentrico

Sede dello studio: Pavia, Italy

Lugano, Switzerland

Vienna, Austria

Durata: 01.01.2015 - 31.12.2018

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Enrico Baldi

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36713

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A Multicenter International Randomized Controlled Manikin Study on Different Protocols of Cardiopulmonary Resuscitation for Laypeople


1. Hypothese / Ziel
Compression-only cardiopulmonary resuscitation (CPR) is a suggested tech- nique for laypeople facing out-of-hospital cardiac arrest (OHCA). However, it is difficult perform- ing high-quality CPR until emergency medical services arrival with this technique. We aimed to verify whether incorporating intentional interruptions of different frequency and duration increases laypeople's CPR quality during an 8-minute scenario compared with compression-only CPR.

2. Studiendesign / Prozesse
We performed a multicenter randomized manikin study selecting participants from 2154 consecutive laypeople who followed a basic life support/automatic external defibrillation course. People who achieved high-quality CPR in 1-minute test on a computer- ized manikin were asked to participate. Five hundred seventy-six were enrolled, and 59 were later excluded for technical reasons or incorrect test recording. Participants were randomized in an 8-minute OHCA scenario using 3 CPR protocols (30 compressions and 2-second pause, 30c2s; 50 compressions and 5-second pause, 50c5s; 100 compressions and 10-second pause, 100c10s) or compression-only technique. The main outcome was the percentage of chest compressions with adequate depth.

3. Ergebnis / Endpunkt

Results: Five hundred seventeen participants were evaluated. There was a statistically sig- nificant difference regarding the percentage of compressions with correct depth among the groups (30c2s, 96%; 50c5s, 96%; 100c10s, 92%; compression only, 79%; P = 0.006). Post hoc comparison showed a significant difference for 30c2s (P = 0.023) and for 50c5s (P = 0.003) versus compression only. Regarding secondary outcome, there were a higher chest compression fraction in the compression-only group and a higher rate of pauses lon- ger than 10 seconds in the 100c10s.

Conclusions: In a simulated OHCA, 30c2s and 50c5s protocols were characterized by a higher rate of chest compressions with correct depth than compression only. This could have practical consequences in laypeople CPR training and recommendations.

Scopo dello studio: Altro

Classificazione: Studio controllato randomizzato (RCT)

Multi-/Monocentrico: Multicentrico

Sede dello studio: Pavia, Italy
Palermo, Italy
Robbio, Italy
Pordenone, Italy
Lugano, Switzerland
Lausanne, Switzerland
Cortaillod, Switzerland
Cugy, Switzerland

Durata: 16.04.2016 - 26.04.2019

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Enrico Baldi

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36731

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Leitstellendisposition und deren Qualitätsbewertung


Sanitätsnotrufzentralen (Leitstellen) haben als Teil der Rettungskette eine hohe Verantwortung bezüglich der Aktivierung geeigneter Rettungsmittel. Sie übernehmen eine rechtliche Garantenstellung. Auf der Suche nach Best-Practice-Modellen werden die gesetzlichen Grundlagen, die organisationsinternen Vorgehensweisen der Qualitätsbewertungen und die Auswertungen von Kennzahlen zwischen einer Schweizer und zwei österreichischen Leitstellen verglichen.

Scopo dello studio: Gestione della qualità

Classificazione: Studio non clinico

Multi-/Monocentrico: Multicentrico

Sede dello studio: St.Gallen, Landessicherheitszentrale Burgenland, Leitstelle Notruf Niederösterreich

Durata:

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Günter Bildstein

Commenti:

Contatto: Günter Bildstein

Dateien:

ID: 36203

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An Utstein-based model score to predict survival to hospital admission: The UB-ROSC score


1. Hypothese / Ziel
To develop and validate a multi-parametric practical score to predict the probability of survival to hospital admission of an out-of-hospital cardiac arrest (OHCA) victim by using Utstein Style-based variables.

2. Studiendesign / Prozesse
All consecutive OHCA cases occurring from 2015 to 2017 in two regions, Pavia Province (Italy) and Canton Ticino (Switzerland) were included. We used random effect logistic regression to model survival to hospital admission after an OHCA. We computed the model area under the ROC curve (AUC ROC) for discrimination and we performed both internal and external validation by considering all OHCAs occurring in the aforementioned regions in 2018. The Utstein-Based ROSC (UB-ROSC) score was derived by using the coefficients estimated in the regression model. The score value was obtained adding the pertinent score components calculated for each variable. The score was then plotted against the probability of survival to hospital admission.

3. Ergebnis / Endpunkt
1962 OHCAs were included (62% male, mean age 73 ± 16 years). Age, aetiology, location, witnessed OHCA, bystander CPR, EMS arrival time and shockable rhythm were independently associated with survival to hospital admission. The model showed excellent discrimination (AUC 0.83, 95%CI 0.81-0.85) for predicting survival to hospital admission, also at internal cross-validation (AUC 0.82, 95%CI 0.80-0.84). The model maintained good discrimination after external validation by using the 2018 OHCA cohort (AUC 0.77, 95%CI 0.74-0.80).

Scopo dello studio: Prognosi

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Pavia, Italy

Ticino, Switzeland

Durata: 01.01.2015 - 31.12.2018

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36701

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Real-life time and distance covered by lay first responders alerted by means of smartphone-application: Implications for early initiation of cardiopulmonary resuscitation and access to automatic external defibrillators


1. Hypothese / Ziel
To investigate the distance covered by lay first responders (LFR) alerted for an out-of- hospital cardiac arrest (OHCA), evaluate the time elapsed between mission acceptance and arrival at the OHCA site, as well as the distance between the LFRs to the closest automatic external defibrillator (AED).

2. Studiendesign / Prozesse
The LFR route, thus time, distance information, and the average speed of each responder were estimated. The same methodology was used to calculate the distance between the closest AED and the LFRs, as well as the distance between the AED and OHCA site.

3. Ergebnis / Endpunkt
Between June 1st, 2014 and December 31st, 2017, the LFR network was activated in occasion of 484 suspected OHCAs. 710 LFRs were automatically selected by the application and accepted the mission. On average 1.5 LFRs arrived at the OHCA site. LFRs covered a distance of 1196 m (IQR 596–2314) at a median speed of 6.9 m/s (IQR 4.5–9.8) or 24.8 Km/h. In 4.4% of the cases the speed of the LFRs was compatible with a brisk walk activity (<1.5 m/sec). The total intervention time of an LFR, who first retrieved an AED and then went to the OHCA site, was longer (275 s, IQR: 184 s–414 s) compared to the total intervention time of a LFR (197 s, IQR: 120 s–306 s; p < 0.001), who went to the OHCA site directly without retrieving an AED.

Scopo dello studio: Gestione della qualità

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Pavia, Italy

Durata: 01.06.2014 - 31.12.2017

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Angelo Auricchio

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36711

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Gender differences in presentation and outcome of out-of-hospital cardiac arrest


1. Hypothese / Ziel
We aimed to analyse the outcome of OHCAs occurred in Swiss Canton Ticino according to the victim’s gender.

2. Studiendesign / Prozesse
We performed a retrospective analysis of prospectively collected data of OHCAs since 1st of January 2005 to 31st of December 2017 in Swiss Canton Ticino. When a cardiac arrest is suspected, assisted triage and life support are dispatched and medical assistance is initiated until an ambulance arrives. The Emergency Medical Service (EMS) dispatcher send the ambulance and, in parallel, notifies the alert to the traditional first-responders (police officers and fire brigade), trained in Basic Life Support-Defibrillation (BLS-D) and equipped with an automatic external defibrillator (AED). If conditions are regarded as safe, the first responeders (FR) are notified as well. The latter are mostly lay persons, but even off-duty healthcare providers.

3. Ergebnis / Endpunkt
A total of 3623 patients, 1140 women (31 %) and 2493 men (69%), were included. OHCA in women occurred more often at home (72% versus 63%, respectively, p<0.001) and less frequently it was witnessed (56% versus 63%, respectively, p <0.001). Women were more likely to be older than men (median age 76 versus 69 years old, respectively, p < 0.001).

Conclusions: In our experience, OHCA presentation and outcome significantly differs according to sex. Women presenting with a shockable rhythm had a lower survival compared to male patients due to different clinical presentation (more often occurring at home and unwitnessed) and to delayed time of defibrillation.

Scopo dello studio: Altro

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2005 - 31.12.2017

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Caputo ML

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36735

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Spatial-temporal heterogeneity of out-of-hospital cardiac arrest incidence in Swiss Canton Ticino


1. Hypothese / Ziel
We aimed to determine whether OHCA incidence was homogeneously distributed at municipality level in Swiss Canton Ticino, a large territory including rural and urban areas; to assess areas of increased risk of OHCAs over time, according to demographic characteristics of the resident population and to predict OHCA events at municipality level.

2. Studiendesign / Prozesse
All data regarding OHCAs which occurred in Canton Ticino (Switzerland) from January 1, 2005, through to December 31, 2017 were entered into a prospectively designed registry and geolocated. Demographic characteristics (sex composition and age distribution) at the level of single municipality were collected from the Federal Office of Statistics. Counting and incidences were calculated at level of each municipality, by taking into account gender and age distribution.
The Integrated Nested Laplace Approximation (INLA) was used for estimate OHCA incidences with related uncertainty in a training sample (OHCAs occurred between 2005 and 2015), and to predict OHCA incidences in a validation cohort (OHCAs occurred in 2016-2017).

3. Ergebnis / Endpunkt
A total of 2129 OHCAs of presumed cardiac origin occurred in the 117 municipalities of Canton Ticino. Of those, 564 (27%) had a VT or VF as presenting rhythm. There was a negligible annual fluctuation in the absolute number of OHCA without significant change over time of the overall OHCA incidence. OHCAs occurred prevalently at home (70%), in men (68%) of a median age of 71 years. We observed a concentration of cardiac events in the Southern part of Ticino, with a spatial distribution that followed the geographical configuration of valleys. As expected, the absolute numbers of OHCAs were higher in more populated areas, but some less populated municipalities showed relevant OHCAs incidence, that could be explained with a higher prevalence of male people with an age ≥ 80 years old.

Conclusions: Significant differences in OHCA prevalence and incidence among municipalities were observed. A predictive model taking into account territorial gender and age distribution is able to predict up to 90% of events variability. This approach provides a great opportunity for preventive measures and reduction in access time to OHCA.

Scopo dello studio: Altro

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2005 - 31.12.2017

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Caputo ML

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36733

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Comparative performance assessment of commercially available automatic external defibrillators: A simulation and real-life measurement study of hands-off time


1. Hypothese / Ziel
Early and good quality cardiopulmonary resuscitation (CPR) and the use of automated external defibrillators (AEDs) improve cardiac arrest patients’ survival. However, AED peri- and post- shock/analysis pauses may reduce CPR effectiveness.

2. Studiendesign / Prozesse
The time performance of 12 different commercially available AEDs was tested in a manikin based scenario; then the AEDs recordings from the same tested models following the clinical use both in Pavia and Ticino were analyzed to evaluate the post-shock and post-analysis time.

3. Ergebnis / Endpunkt
None of the AEDs was able to complete the analysis and to charge the capacitors in less than 10 s and the mean post-shock pause was 6.7 ± 2.4 s. For non-shockable rhythms, the mean analysis time was 10.3 ± 2 s and the mean post-analysis time was 6.2 ± 2.2 s. We analyzed 154 AED records [104 by Emergency Medical Service (EMS) rescuers; 50 by lay rescuers]. EMS rescuers were faster in resuming CPR than lay rescuers [5.3 s (95%CI 5–5.7) vs 8.6 s (95%CI 7.3–10).

Scopo dello studio: Gestione della qualità

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Pavia, Italy

Durata: 01.01.2016 - 05.07.2016

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Commenti: the duration of the study is estimated. It took place indicatively in early 2016.

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36709

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Gender-specific differences in return-to-spontaneous circulation and outcome after out-of-hospital cardiac arrest: Results of sixteen-year-state-wide initiatives


1. Hypothese / Ziel
Several studies reported a lower proportion of laypeople cardio-pulmonary resuscitation (CPR) in female victims of out-of-hospital cardiac arrest (OHCA). We aimed to verify how sixteen-years of state-wide initiatives impacted on gender-differences in OHCA treatment and survival.

2. Studiendesign / Prozesse
All the 2481 consecutive OHCAs of presumed cardiac origin occurred between 2002 and 2018 in the Swiss Ticino Canton and in which a resuscitation was attempted, were included. Emergency medical system (EMS)-witnessed OHCAs were excluded.

3. Ergebnis / Endpunkt

Results: Time from call to CPR decreased from 9-min in 20022006 to 5-min in 20152018 (p < 0.01) and until 2014, it was longer in women. Survival to discharge increased overall from 11% in 20022006 to 23% in 20152018 (p<0.001) related to telephone-assisted CPR development (period 2011 2014) and first responder and layperson recruitment via a mobile application (period 20152018). In males, survival increased from 12% to 25% (p = 0.001) with a statistically significant increase in odds of survival in 20072010 (OR 1.6 95%CI 1.12.3; p = 0.001), in 20112014 (OR 2 95%CI 1.4 2.8; p = 0.001), and in 20152018 (2.4 95%CI 1.73.3; p = 0.001) compared to 20022006. On the other hand, in females, survival increased from 7% to 18% (p < 0.001), with a corresponding increase in the odds of survival of almost 3 times from 20022006 to 20152018 time period (OR 2.9 95%CI 1.55.8, p=0.001). No difference in survival probability was observed according to gender when adjusted for age, presenting rhythm, year-groups, OHCA location, EMS arrival time, witnessed status and laypeople-CPR.

Conclusions: State-wide initiatives can significantly increase the chances of survival in both male and female victims of OHCAs, by increasing the probability to receive CPR in a shorter time span.

Scopo dello studio: Altro

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2002 - 31.12.2018

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Angelo Auricchio

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36729

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Lay persons alerted by mobile application system initiate earlier cardio-pulmonary resuscitation: A comparison with SMS-based system notification


1. Hypothese / Ziel
We compared the time to initiation of cardiopulmonary resuscitation (CPR) by lay responders and/or first responders alerted either via Short Message Service (SMS) or by using a mobile application-based alert system (APP).

2. Studiendesign / Prozesse
The Ticino Registry of Cardiac Arrest collects all data about out-of-hospital cardiac arrests (OHCAs) occurring in the Canton of Ticino. At the time of a bystander’s call, the EMS dispatcher sends one ambulance and alerts the first-respon- ders network made up of police officers or fire brigade equipped with an automatic external defibrillator, the so called “traditional” first responders, and – if the scene was considered safe – lay responders as well. We evaluated the time from call to arrival of traditional first responders and/or lay responders when alerted either via SMS or the new developed mo- bile APP.

3. Ergebnis / Endpunkt
Over the study period 593 OHCAs have occurred. Notification to the first responders network was sent via SMS in 198 cases and via mobile APP in 134 cases. Median time to first responder/lay responder arrival on scene was sig- nificantly reduced by the APP-based system (3.5 [2.8–5.2]) compared to the SMS-based system (5.6 [4.2–8.5] min, p 0.0001). The proportion of lay responders arriving first on the scene significantly increased (70% vs. 15%, p < 0.01) with the APP. Earlier arrival of a first responder or of a lay responder determined a higher survival rate.

Scopo dello studio: Gestione della qualità

Classificazione: Studio controllato randomizzato (RCT)

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2012 -31.12.2015

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36707

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Validation of the return of spontaneous circulation after cardiac arrest (RACA) score in two different national territories


1. Hypothese / Ziel
To test the ability of the RACA score to predict the probability of ROSC in two different regions with different local resuscitation networks: the Swiss Canton Ticino and the Italian Province of Pavia.

2. Studiendesign / Prozesse
All OHCAs occurred between January 1st 2015 and December 31st 2017 were included. The original regression coefficients for all RACA score variables were applied. The probability to obtain the ROSC as measured with the RACA score was divided in tertiles. Overall, 2041 OHCAs were included in the analysis. The RACA score showed good discrimination for ROSC (AUC 0.76) and calibration, without interaction (p 0.28) between the region and the probability of ROSC. The probability of ROSC was 15% for RACA scores 0.42.

3. Ergebnis / Endpunkt
The application of the RACA score reliably assess the probability to obtain the ROSC, with equal effectiveness in the two regions, despite different organization of the resuscitation network. Patients with a RACA score >0.42 had more than 50% probability to obtain ROSC.

Scopo dello studio: Prognosi

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Pavia, Italy

Ticino, Switzerland

Durata: 01.01.2015 - 31.12.2017

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Maria Luce Caputo

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36745

Basec ID:

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Patient voluntarily delays call to emergency medical system for ST-elevation myocardial infarction during COVID-19 pandemic


1. Hypothese / Ziel
An increase in the time from the symptoms onset to first medical contact and to primary percutaneous coronary intervention (pPCI) has been observed in countries with high-incidence of COVID-19 cases. We aimed to verify if there was any change in the patient delay and in the EMS response times up to the pPCI for STEMI patients in Swiss Ticino Canton.

2. Studiendesign / Prozesse
We assessed STEMI management including time from symptoms onset to EMS call, time of EMS response, time to pPCI in Swiss Canton Ticino. Data were retrieved from the Acute-Coronary-Syndrome- Ticino-Registry. We considered the patients included in the registry from March to May 2020 (pandemic period) and then from June to August 2020 (post-pandemic period) in whom a pPCI was performed. We compared these patients to those undergoing a pPCI in the same months in the year 2016–2019.

3. Ergebnis / Endpunkt
During the pandemic period, the time from symptoms onset to pPCI significantly increased com- pared to non-pandemic periods. This was due to a significant prolongation of the time from symptoms onset to EMS call, that nearly tripled. In contrast, after the pandemic period, there was a significantly shorter time from symptom onset to EMS call compared to non-pandemic years, whereas all other times remained unchanged.

Scopo dello studio: Altro

Classificazione: Studio caso-controllo

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Pavia, Italy

Durata: 01.03.2020 - 31.08.2020

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Enrico Baldi

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36715

Basec ID:

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A quantitative assessment of the contribution of “citizen First Responder” in the adult out-of- hospital chain of survival during COVID-19 pandemic


1. Hypothese / Ziel
Assessing and estimating the influence of "citizen first responders" in the adult out-of-hospital survival chain.

2. Studiendesign / Prozesse
During pandemic, scientific societies stressed the importance of donning personal pro- tective equipment (PPE) before intervening3; furthermore some FRs system were temporarily suspended or limited to “professional FRs”.2 Also in Swiss Canton Ticino only the activation “professional FRs” activity was maintained. This situation provides the unique opportunity to quantitatively assess the contribution of “citizen FRs” in OHCA resuscitation including AED use before EMS arrival.
Using data from a prospective Utstein-based registry,4,5 we com- pared the clinical characteristics and key resuscitation parameters of OHCAs occurred when the “citizen FRs” activation was halted (03/ 03/2020–26/06/2020; COVID-period) to those OHCAs occurring dur- ing the three months immediately after (27/06/2020–30/09/2020; Post-COVID period), and finally to those occurring in an historical period before COVID-19 pandemic (03/03–26/06 of years 2016– 2019; Historical periods).

3. Ergebnis / Endpunkt
Summarizing, “citizen FRs” represent an important element in OHCA management accounting for about 15% of CPR initiated before EMS arrival.

Scopo dello studio: Altro

Classificazione: Studio caso-controllo

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Pavia, Italy

Durata: 03.03.2020 - 30.09.2020

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Enrico Baldi

Commenti: This is a published letter to the editor

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36717

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Better management of out-of-hospital cardiac arrest increases survival rate and improves neurological outcome in the Swiss Canton Ticino


1. Hypothese / Ziel
To determine the incidence of out-of-hospital cardiac arrest (OHCA) fulfilling Utstein criteria in the Canton Ticino,
Switzerland, the survival rate of OHCA patients and their neurological outcome.

2. Studiendesign / Prozesse
All OHCAs treated in Canton Ticino between 1 January 2005 and 31 December 2014 were followed until either death
or hospital discharge. The survival and neurological outcome of those OHCA fulfilling Utstein criteria are reported.

3. Ergebnis / Endpunkt
A total of 3367 OHCAs occurred in the Canton Ticino over a 10-year period. Resuscitation was attempted in 2298 patients; of those 1492 (65%) were of presumed cardiac origin, 454 fulfilling the Utstein comparator criteria. About 69% [95% confidence interval (CI), 66.6–71.4%] of the patients had a bystander-witnessed arrest; a dispatched cardiopulmonary resuscitation (CPR) steadily and significantly increased from 2005 to 2014. Out-of-hospital cardiac arrest occurred prevalently home (67%), in men (71%) of a mean age of 71 + 13 years. There were no statistically significant differences either in demographic characteristics of OHCA victims over these years or in presenting rhythm. There was a progressive increase in the survival at discharge from 15% in 2005 to 55% in 2014; overall 96% (95% CI, 93.3 – 99.9%) of the survivors had a good neurological outcome.

Scopo dello studio: Altro

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Pavia, Italy

Durata: 01.01.2005 - 31.12.2014

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Romano Mauri

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36721

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NON-PROFESSIONAL FIRST RESPONDERS: ORGANIZATIONAL EFFICIENCY CRITERIA IN TICINO (SOUTHERN SWITZERLAND)


1. Hypothese / Ziel
Assess efficiency of the organizational model which has been developed in Ticino as of 2006 and is characterized by an alarm system and non professional "First Responder" (FR) (police, fire brigade, border patrol, citizens, etc.) interventions which are complementary to professional emergency services whose intervention time in average is of about 9 minutes. The service is managed and coordinated by "Ticino Soccorso 144", counts approx. 2'500 members and is activated through short text message (SMS) in case of a suspected heart attack. The FR's response is thus based on principles of randomness and voluntariness.

2. Studiendesign / Prozesse
Measurements of the hereafter listed indicators through the analysis of 816 questionnaires filled in on-line by the FR following their interventions during the period 1.1.2006-31.12.2012:
-Roll time (SMS Alert - FR starts to move)
-Response time (FR starts to move - Arrival on scene)
-Decreased therapeutic interval (at-patient time without EMS).

3. Ergebnis / Endpunkt
The results show the roll and response time are optimal, although the number of cases in which the FR can perform cardiopulmonary resuscitation before the ambulance's arrival might be improved. The effectiveness of the FR alarm system should be assessed and measured in the future.

Scopo dello studio: Gestione della qualità

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2006 - 31.12.2012

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Claudio Benvenuti

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36739

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EFFECTIVENESS AND COST-EFFECTIVENESS OF OHCA-EARLY DEFIBRILLATION PROGRAM (EDP) IN SOUTHERN SWITZERLAND


1. Hypothese / Ziel
In 2006 Ticino Cuore Foundation started an early defibrillation program in southern Switzerland including com- munity BLSD training, PAED and first responder network. Aim of the present work was to evaluate effectiveness and cost-effectiveness of the OHCA early defibrillation program.

2. Studiendesign / Prozesse
The study compared clinical data (Utstein style) and economic outcomes before and after EDP implementa- tion. We used 2002-2005 as control and 2008-2012 as the intervention period. Primary clinical outcomes were: ROSC at ED admission, survival to hospital discharge and good cerebral performance (CPC 1 or 2). We applied logistic regression to compare outcomes, estimating adjusted OR using sex, age, etiology, lay wit- ness, bystander BLS and location as covariates. For economic evaluation we used a cost effectiveness analy- sis, comparing cost difference to clinical difference. We considered direct cost of implementation, as person- nel, AEDs, BLSD training, marketing and other costs.

3. Ergebnis / Endpunkt
The analysis considered 1,104 OHCA before (mean age 66,3) and 1,307 (67,9) after implementation. ROSC showed an increasing trend (19.30% before and 22.50% after; adjusted OR = 1.226 p = 0.086), while sur- vival to hospital discharge showed a significant increase (7.00% before vs 9.80% after, adjusted OR = 1.476 p = 0.028). In particular, survival to hospital discharge with CPC 1-2 increases (5.80% before vs 9.30% af- ter, adjusted OR = 1.712 p =0.004). We calculated that the program saved 9 more lives per year with good cerebral performance (16 before vs 25 after). In the same period we measured that the total cost of the program was 3.417.856 CHF Considering a conservative mean survival of 5 years for each patients, cost effectiveness results were 15,190 CHF per life year saved (16,601 $), less than 50,000 $, the US standard generally accepted per life year saved (1).

Scopo dello studio: Economia sanitaria

Classificazione: Studio caso-controllo

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2008 - 31.12.2012

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36705

Basec ID:

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PUBLIC DEFIBRILLATORS AND VANDALISM: MYTH OR REALITY?


1. Hypothese / Ziel
Our presentation shall both quali- fy and quantify the vandalism suffered during the cantonal programme of placing defibrillators in public locations in the period 2008 - 2012.

2. Studiendesign / Prozesse
Data involving vandalism on the 142 public defibrillators placed within the cantonal territory were collected from 1.1.2008 to 31.12.2012. We then classified these data ac- cording to type, seriousness and risk for the patient’s health.

3. Ergebnis / Endpunkt
The study performed shows that during the period taken into consideration, the number of acts of vandalism, on defibrillators placed in public locations was extremely reduced and there were certainly no events which could have jeopardized the patient’s security and/or health. It must also be highlighted that this might be the result of the awareness campaign and training cours- es offered to the volunteers performed during the whole early defibrillation programme. Thus the worry that there might be acts of vandalism, even if legitimate, cannot become an obstacle for the diffusion of defibrillators in public locations.

Scopo dello studio: Economia sanitaria

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2008 - 31.12.2012

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36703

Basec ID:

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A Bayesian spatiotemporal statistical analysis of out-of-hospital cardiac arrests


1. Hypothese / Ziel
We propose a Bayesian spatiotemporal statistical model for predicting out-of-hospital cardiac arrests (OHCAs).

2. Studiendesign / Prozesse
Risk maps for Ticino, adjusted for demographic covariates, are built for explaining and forecasting the spatial distribution of OHCAs and their temporal dynamics. The occurrence intensity of the OHCA event in each area of inter- est, and the cardiac risk-based clustering of municipalities are efficiently estimated, through a statistical model that decomposes OHCA intensity into overall intensity, demographic fixed effects, spatially structured and unstructured random effects, time polynomial dependence, and spatiotemporal random effect.

3. Ergebnis / Endpunkt
In the studied geography, time evolution and dependence on demographic features are robust over different cat- egories of OHCAs, but with variability in their spatial and spatiotemporal structure. Two main OHCA incidence-based clusters of municipalities are identified.

Scopo dello studio: Altro

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Milan, Italy

Pavia, Italy

Durata: 01.01.2019 - 30.05.2019

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Stefano Peluso

Commenti: The duration of this study is estimated. it took place indicatively between the end of 2018 and the beginning of 2019.

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36723

Basec ID:

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Association Between Postresuscitation 12-Lead ECG Features and Early Mortality After Out-of-Hospital Cardiac Arrest: A Post Hoc Subanalysis of the PEACE Study


1. Hypothese / Ziel
Once the return of spontaneous circulation after out-of-hospital cardiac arrest is achieved, a 12-lead ECG is strongly recommended to identify candidates for urgent coronary angiography. ECG has no apparent role in mortality risk stratification. We aimed to assess whether ECG features could be associated with 30-day survival in patients with out-of- hospital cardiac arrest.

2. Studiendesign / Prozesse
All the post-return of spontaneous circulation ECGs from January 2015 to December 2018 in 3 European centers (Pavia, Lugano, and Vienna) were collected. Prehospital data were collected according to the Utstein style. A total of 370 ECGs were collected: 287 men (77.6%) with a median age of 62years (interquartile range, 53–70years). After correction for the return of spontaneous circulation-to-ECG time, age >62years (hazard ratio [HR], 1.78 [95% CI, 1.21–2.61]; P=0.003), female sex (HR, 1.5 [95% CI, 1.05–2.13]; P=0.025), QRS wider than 120ms (HR, 1.64 [95% CI, 1.43–1.87]; P<0.001), the presence of a Brugada pattern (HR, 1.49 [95% CI, 1.39–1.59]; P1 segment (HR, 1.75 [95% CI, 1.59–1.93]; P<0.001) were independently associated with 30-day mortality. A score ranging from 0 to 26 was created, and by dividing the population into 3 tertiles, 3 classes of risk were found with significantly different survival rate at 30days (score 0–4, 73%; score 5–7, 66%; score 8–26, 45%).

3. Ergebnis / Endpunkt
The post-return of spontaneous circulation ECG can identify patients who are at high risk of mortality after out-of- hospital cardiac arrest earlier than other forms of prognostication. This provides important risk stratification possibilities in post- cardiac arrest care that could help to direct treatments and improve outcomes in patients with out-of-hospital cardiac arrest.

Scopo dello studio: Diagnosi

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Pavia, Italy

Lugano, Switzerland

Vienna, Austria

Durata: 01.01.2015 - 31.12.2018

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Francesca Romana Gentile, MD

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36725

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End-tidal carbon dioxide (ETCO2) at intubation and its increase after 10 minutes resuscitation predicts survival with good neurological outcome in out-of-hospital cardiac arrest patients


1. Hypothese / Ziel
To evaluate whether end-tidal carbon dioxide (ETCO2) value at intubation and its early increase (10 min) after intubation predict both the sur- vival to hospital admission and the survival at hospital discharge, including good neurological outcome (CPC 1–2), in patients with out-of-hospital cardiac arrest (OHCA).

2. Studiendesign / Prozesse
All consecutive OHCA patients of any etiology between 2015 and 2018 in Pavia Province (Italy) and Ticino Region (Switzerland) were considered. Patients died before ambulance arrival, with a “do-not-resuscitate” order, without ETCO2 value or with incomplete data were excluded.

3. Ergebnis / Endpunkt

Results: The study population consisted of 668 patients. An ETCO2 value at intubation > 20 mmHg and its increase 10 min after intubation were independent predictors (after correction for known predictors of OHCA outcome) of survival to hospital admission and survival at hospital discharge. Relative to hospital discharge with good neurological outcome, ETCO2 at intubation and its 10-min change were confirmed predictors both individ- ually and in a bivariable analysis (OR 1.83, 95 %CI 1.02–3.3; p = 0.04 and OR 3.9, 95 %CI 1.97–7.74; p < 0.001, respectively). This was confirmed also when accounting for gender, age, etiology and location. After further adjustment for bystander and CPR status, presenting rhythm and EMS arrival time, the ETCO2 change remained an independent predictor.

Conclusions: ETCO2 value > 20 mmHg at intubation and its increase during resuscitation improve the prediction of survival at hospital discharge with good neurological outcome of OHCA patients. ETCO2 increase during resuscitation is a more powerful predictor than ETCO2 at intubation. A larger prospective study to confirm this finding appears warranted.

Scopo dello studio: Prognosi

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Pavia, Italy

Lugano, Ticino, Switzerland

Durata: 01.01.2015 - 31.12.2018

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Enrico Baldi

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien:

ID: 36727

Basec ID:

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Spatio-temporal prediction model of out-of- hospital cardiac arrest: Designation of medical priorities and estimation of human resources requirement


1. Hypothese / Ziel
To determine the out-of-hospital cardiac arrest (OHCA) rates and occurrences at municipality level through a novel statistical model accounting for temporal and spatial heterogeneity, space-time interactions and demographic features. We also aimed to predict OHCAs rates and number at municipality level for the upcoming years estimating the related resources requirement.


2. Studiendesign / Prozesse
All the consecutive OHCAs of presumed cardiac origin occurred from 2005 until 2018 in Canton Ticino region were included. We implemented an Integrated Nested Laplace Approximation statistical method for estimation and prediction of municipality OHCA rates, number of events and related uncertainties, using age and sex municipality compositions. Comparisons between predicted and real OHCA maps validated our model, whilst compari- sons between estimated OHCA rates in different yeas and municipalities identified significantly different OHCA rates over space and time. Longer-time predicted OHCA maps provided Bayesian predictions of OHCA coverages in varying stressful conditions.

3. Ergebnis / Endpunkt
2344 OHCAs were analyzed. OHCA incidence either progressively reduced or continuously increased over time in 6.8% of municipalities despite an overall stable spatio-temporal distribution of OHCAs. The predicted number of OHCAs accounts for 89% (2017) and 90% (2018) of the yearly variability of observed OHCAs with prediction error ≤ 1OHCA for each year in most municipalities. An increase in OHCAs number with a decline in the Automatic External Defibrillator availability per OHCA at region was estimated.

Conclusions: Our method enables prediction of OHCA risk at municipality level with high accuracy, providing a novel approach to estimate resource allocation and anticipate gaps in demand in upcoming years.

Scopo dello studio: Altro

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Pavia, Italy

Durata: 01.01.2005 - 31.12.2018

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Angelo Auricchio

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36747

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Fifty percent survival of cardiac arrest in Switzerland: an utopian goal?


1. Hypothese / Ziel
In June 2006 we implemented in Southern Switzerland (2811 km2/320.00 inhabitants) an Early Resuscitation and Defibrillation Program creating a network of "first responders" coordinated by the regional dispatch centre. This is the first program of this kind in Switzerland. We tested the possibility of reaching a survival rate of 50% of witnessed VF/VT within the next years.

2. Studiendesign / Prozesse
We collected data according to the Utstein style and tested our hypothesis using a linear regression equation.

3. Ergebnis / Endpunkt
The predicted percentage of patients leaving Hospital increases by 5,1% per year.

Conclusions: The data suggest that it would be statistically possible to attain our survival goal also considering the regression line with the smaller slope. To stabilise the trend for better survival rate the number of bystander CPR must be improved.
To reach this goal, a cultural change in our population is necessary and for this reason we have already implemented an educational program to teach the resuscitation manoeuvres to all teenagers in the last year of compulsory school (fourteen-year-old).

Scopo dello studio: Altro

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2005 - 31.12.2009

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: R.Mauri

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36737

Basec ID:

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Bystander CPR beats AED improving the survival rate of out-of-hospital cardiac arrest


1. Hypothese / Ziel
We studied the relative importance of bystander CPR and the number of AED in our region in term of survival of VF/VT cardiac arrest.

2. Studiendesign / Prozesse
In June 2006 we implemented in Southern Switzerland an “Early Resuscitation and Defibrillation Program”, creating a network of “first responders” coordinated by the regional dispatch center.
Our population of 320.000 inhabitants is distributed over an area of 2812 square kilometers with, urban, rural and mountainous regions.
We collected data according to the Utstein style and inserted them in a multiple regression formula.

3. Ergebnis / Endpunkt
The survival is strictly related to the number of bystand- ers CPR and AED. Currently, to raise the survival rate the increase of bystander CPR is more effective than in- creasing AED units. The "a value" (2.3720) is based on the quality of EMS and other not related factors.
At present, to get the same survival rate we would need 9 to 10 more AED for each bystander CPR.

Scopo dello studio: Gestione della qualità

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2005 - 31.12.2009

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: R. Mauri

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36741

Basec ID:

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Out-of-hospital management and outcome of ST-elevation acute coronary syndromes in Swiss Canton Ticino: 10 years of the preH-ACS registry


1. Hypothese / Ziel
Acute coronary syndrome (ACS) with ST elevation (STE) is one of the most frequent causes of emergency medical services (EMS) activation. Moreover, about 10% of ACS are complicated by out-of-hospital cardiac arrest (OHCA).
Pre-hospital management of these patients have to be provided by a fast and well- organized network in order to improve chance of survival with a good outcome. Aim of this study was to evaluate STE-ACS incidence, management and outcome in Swiss Canton Ticino and to assess prevalence and clinical characteristics of patients presenting with an OHCA during STE-ACS. Finally we investigated clinical predictors which may help to identify patients with a higher risk of OHCA during STE-ACS.

2. Studiendesign / Prozesse
We performed a retrospective analysis of prospectively collected data of STE-ACS Registry since 1st of January 2010 to 31st of December 2020 in Swiss Canton Ticino.
Since 2010, the preH-ACS registry enrolled all patients with a confirmed Hospital diagnosis of STE-ACS.
All data including hemodynamics, arrhythmias occurrence, pre-hospital clinical management and timing of intervention were collected.


3. Ergebnis / Endpunkt
A total of 2015 STE-ACS occurred in Canton Ticino (male gender 72%). Of them, 902 were fully managed in the out-of-hospital setting (45%) and 1113 (55%) self-presented at the Hospital Emergency Room. Prevalence on the territory significantly varied, with a higher proportion of events in the biggest urban agglomerates. Yearly incidence ranged from 51 per 100’000 inhabitants/year in 2010, to 42 per 100’000 inhabitants/year in 2020. Times of intervention were largely within those recommended in International Guidelines (see figure below).
A total of 88 patients (10%) had an OHCA during STE-ACS, 46 (52%) before EMS arrival and 42 (48%) after first medical contact (FMC). Yearly proportion of OHCA ranged from 4% to 15% over years without a statistically significant trend. Overall, 67% of patients who suffered from an OHCA during STE-ACS showed a shockable first rhythm. This proportion raised to 90% in the EMS witnessed group. Clinical characteristics and outcome in OHCA group respect to STE-ACS were reported in the table. Patients who had an OHCA were significantly younger and more often males.
OHCA patients were more often transported to the hospital with a combination of ambulance and helicopter, as compared with STE-ACS patients without OHCA (26% versus 13%, p 0.03). Median time of ambulance arrival did not significantly differ between the two groups as well as the median time to reperfusion.
Mortality was 4 times-higher in OHCA patients (17% versus 4%, p 0.002).
At multivariable regression analysis, a low systolic blood pressure (<90 mmHg) and the younger age were associated with a higher probability to have an OHCA.

Conclusions: Yearly incidence of ST elevation Acute Coronary syndromes in Swiss Canton Ticino was almost stable over years, with a territorial prevalence of events largely related to urban areas distribution. In line with international data, in our region out-of-hospital cardiac arrest complicates up to 15% of STE-acute coronary syndromes. A high percentage of hospital self-presented patients with STE-ACS (55%) was observed. This observation requires further interventions to raise awareness about importance of early activation of the EMS network in case of chest pain.

Scopo dello studio: Prevenzione

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: Ticino, Switzerland

Durata: 01.01.2010 - 31.12.2020

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Caputo ML

Commenti:

Contatto: Fondazione Ticino Cuore, Via alla Campagna 4, 6900 Lugano, CH

Dateien: Datei 1

ID: 36743

Basec ID:

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Swiss Registry of Cardiac Arrest (SWISSRECA)


Registrierung aller ausserklinischen plötzlichen Herzstillstände (OHCA) in der Schweiz, bei denen das Rettungssystem aktiviert wurde (Rettungskette).
Enregistrement de tous les arrêts cardiaques soudains (OHCA) extrahospitaliers en Suisse pour lesquels le système de sauvetage a été activé (chaîne de sauvetage).
Registrazione di tutti gli arresti cardiaci improvvisi extraospedalieri (OHCA) in Svizzera per i quali è stato attivato il sistema di soccorso (catena di soccorso).

Scopo dello studio: Ricerca sui sistemi sanitari

Classificazione: Studio di coorte

Multi-/Monocentrico: Multicentrico

Sede dello studio: DE: https://www.144.ch/qualitaetssicherung/swissreca/
FR: https://www.144.ch/fr/assurance-qualite/swissreca/
IT: https://www.144.ch/it/controllo-qualita/swissreca/

Durata: 01.01.2018 -

Attivo/inattivo: Attivo

Reclutamento: Stiamo cercando ulteriori sedi di studio

Proprietario: Interverband für Rettungswesen

Commenti: DE: Wir rekrutieren Spitäler, die Patienten nach einer Reanimation aufnehmen FR: Nous recrutons des hôpitaux qui accueillent des patients en post-réanimation. IT: Stiamo reclutando ospedali che accolgono pazienti post rianimazione

Contatto: André Wilmes

Dateien:

ID: 36161

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Analisi del rischio delle divise per soccorritori dei servizi ambulanza affiliati alla FCTSA


1. Ipotesi / Obiettivo
2. Design dello studio / Process
3. Risultato / Endpoint

Scopo dello studio: Gestione della qualità

Classificazione: Studio non clinico

Multi-/Monocentrico: Multicentrico

Sede dello studio: Canton Ticino e Moesano

Durata: GG.MM.AAAA - GG.MM.AAAA

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: FCTSA

Commenti: In seguito alle direttive dell’Interassociazione di Salvataggio [IAS] emanate nel 2017 che hanno definito precisi standard prestazionali per l’equipaggiamento dei soccorritori del servizio ambulanza, i servizi del Canton Ticino e del Moesano, attraverso il loro organo rappresentativo, la Federazione Cantonale Ticinese Servizi Autoambulanze [FCTSA], hanno richiesto allo studio Widmer CEC SA l’allestimento della analisi di rischio relativa alle divise dei soccorritori del servizio ambulanza e dei Dispositivi di Protezione Individuale [DPI] in dotazione con l’obiettivo di individuare la soluzione più confacente dal punto di vista della sicurezza, dell’ergonomia, della vestibilità e, conseguentemente, economico.

Contatto: Daniel Pasquali

Dateien:

ID: 36460

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Valutazione soddisfazione pazienti soccorsi dai servizi ambulanza del Canton Ticino e Moesano 2015-2016


1. Ipotesi / Obiettivo
Valutare il grado di soddisfazione degli utenti rispetto alle prestazioni fornite dai servizi di soccorso affiliati alla FCTSA ed evidenziare eventuali differenze tra i risultati delle due indagini in esame. In entrambe le indagini è stato valutato il livello globale di soddisfazione nei confronti dell’intervento con una domanda specifica, così come il grado di soddisfazione per “Relazione e comunicazione”, “Cura” (“Cura e trattamento del dolore” nell’indagine 2004-2005) e “Comfort dei mezzi di soccorso” tramite tre batterie di domande.

2. Design dello studio / Processi
I dati sono stati raccolti utilizzando due formulari distinti per soccorso e trasporto. Le domande e i formulari sono stati validati in una fase precedente nel 2004.
I dati sono stati raccolti durante il periodo giugno 2015-agosto 2016 dalla FCTSA, che li ha organizzati in una banca dati in formato ACCESS. Questa banca dati e quella relativa all’indagine 2004-2005 sono state poi fornite alla SUPSI che le ha analizzate utilizzando il programma Excel 2016 e il programma statistico Stata vs 14.1.
Per la rappresentare la performance dei singoli servizi, le risposte (originariamente codificate sulla base di una scala Likert a 5 posizioni) sono state ricodificate. Le aree di analisi sono messe in relazione a fattori sociodemografici, informazione e comunicazione, comfort dei mezzi, numero di soccorritori intervenuti e i tempi di attesa.
3. Risultato / Endpoint+
In generale, in entrambe le indagini si riscontra una correlazione elevata e positiva tra i valori medi di soddisfazione e importanza (r=0.80 per l’indagine 2015-2016; r=0.70 per l’indagine 2004-2005); ciò significa che all’aumentare dell’importanza attribuita ai vari aspetti aumenta anche il grado di soddisfazione.
Il grado di soddisfazione espresso dai pazienti è sempre molto elevato.

Scopo dello studio: Gestione della qualità

Classificazione: Studio non clinico

Multi-/Monocentrico: Multicentrico

Sede dello studio: Canton Ticino e Moesano

Durata: 01.06.2015 - 31.08.2016

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: FCTSA

Commenti: Interessante anche condividere alcuni elementi di struttura del formulario. Lo strumento di rilevazione dovrà essere modificato: - snellire il questionario rilevando soltanto la soddisfazione? Questo potrebbe risultare utile per aumentare il tasso di risposta. - l’ambito professionale è un dato utile? - è necessario che il livello formativo del paziente sia rilevato in modo così dettagliato? - ev. rivedere le categorie di risposta di alcune domande per evitare formulazioni poco chiare (es.: tempo di attesa dell’ambulanza). Il formulario é stato somministrato a pazienti che erano in grado di valutare la prestazione.

Contatto: Daniel Pasquali

Dateien: Datei 1

ID: 36462

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Registri First Hour Quintet


1. Ipotesi / Obiettivo
Monitoraggio delle prestazioni offerte nelle 5 sindromi considerate dal FHQ

2. Design dello studio / Processi
Attraverso algoritmi/atti medico delegati e strumenti di rilevamento dei dati, si é automatizzato il processo di raccolta del dato, del controllo della qualità del dato e della reportisitica.

3. Risultato / Endpoint+
I servizi affiliati alla FCTSA dispongono di un cruscotto digitale che in tempo reale permette di evidenziare i KPI previsti per le patologie tempo dipendenti. Questo oltre ai dati necessari per l'accerditamento IAS.

Scopo dello studio: Gestione della qualità

Classificazione: Altro

Multi-/Monocentrico: Multicentrico

Sede dello studio: FCTSA e Moesano

Durata: GG.MM.AAAA - GG.MM.AAAA

Attivo/inattivo: Attivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: FCTSA

Commenti: Fino al 2022 i dati specifici dei registri venivano raccolti in una seconda fase, dopo l'intervento. Venivano inseriti in un database web e i risultati venivano inseriti in un portale intranet. Con il nuovo progetto della cartella clinica informatizzata 2.0 (I servizi della FCTSA già dal 1997 utilizzavano una cartella informatizzata ma veniva informatizzata in un secondo tempo. Dal 2022 la cartella clinica informatizzata é uno strumento che permette la raccolta dati in tempo reale e funge anche da check-list secondo ABCDE, da strumento di comunicazione con gli ospedali. In questo nuovo strumento, che raccoglie in automatico anche i dati biometrici del paziente dai dispositivi medici in dotazione, sono stati aggiunti tutti i dati necessari per la valutazione dei pazienti FHQ che erano invece presenti in un portale separato. I servizi della FCTSA dispongono oggi di uno strumento di analisi degli interventi che permette di evidenziare i risultati (Criteri 8 accreditamento IAS: operativi clinici) per le situazioni di ACR, STROKE, Sindrome coronarica acuta, Insufficienza respiratoria acuta, Politrauma. Queste informazioni sono disponibili direttamente via web in tempo reale dagli operatori e dal personale che interviene e possono essere messe in relazione a trend storici oppure filtrati per area geografica. Il processo di gestione del dato viene applicato utilizzando strumenti informatici che permettono un alto livello di dataquality e data "cleaning".

Contatto: Daniel Pasquali

Dateien: Datei 1

ID: 36464

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ITED project – Introduzione della trasmissione ECG a dodici derivate come attività di processo per il trattamento dello STEMI nel Canton Ticino e Moesano


1. Ipotesi / Obiettivo
Verificare apparecchiature e procedura di comunicazione con l'unità di cardiologia invasiva per garantire il gold standard di trattamento del paziente con STEMI secondo le linee guida internazionali (versione 2005-2010)

2. Design dello studio / Processi
Processo di analisi degli strumenti e validazione della qualità dell'immagine trasmessa. Valutare la procedura di contattao e trasporto diretto alla cardiologia invasiva da tutto il territorio cantonale.

3. Risultato / Endpoint+
alla fine del 2011 tutti i servizi della FCTSA trasmettevano secondo procedure i pazienti con STEMI e é stato realizzato uno strumento di analisi delle performance (Registro prev-SCA)

Scopo dello studio: Terapia

Classificazione: Studio non clinico

Multi-/Monocentrico: Multicentrico

Sede dello studio: Canton Ticino - sopraceneri

Durata: 2008 - 2011

Attivo/inattivo: Attivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: FCTSA

Commenti: Il progetto ha definito una procedura che é diventata un atto medico delegato ed é stata integrata nei processi di cura del preospedaliero. Viene costantemente monitorizzata attraverso un apposito registro e dai risultati emersi il 90% dei pazienti con STEMI viene ricoverato direttamente in cardiologia invasiva e i tempi di arrivo sul posto arrivo in H sono mediamente di 70 minuti (fonte registri FCTSA).

Contatto: Daniel Pasquali

Dateien: Datei 1 Datei 1 Datei 1

ID: 36466

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Out-of-hospital cardiac arrests and mortality in Swiss Cantons with high and low COVID-19 incidence: A nationwide analysis


Aims: Many countries reported an increase of out-of-hospital cardiac arrests (OHCAs) and mortality during the COVID-19 pandemic. However, all these data refer to regional settings and national data are still missing. We aimed to assess the OHCA incidence and population mortality during COVID-19 pandemic in whole Switzerland and in the different regions (Cantons) according to the infection rate.
Methods: We considered OHCAs and deaths which occurred in Switzerland after the first diagnosed case of COVID-19 (February 25th) and for the subsequent 65 days and in the same period in 2019. We also compared Cantons with high versus low COVID-19 incidence
Conclusions: During the COVID-19 pandemic in Switzerland mortality increased in Cantons with high-incidence of infection, whilst not in the lowincidence ones. OHCA occurrence followed an opposite trend showing how variables related to the health-system and EMS organization deeply influence OHCA occurrence during a pandemic.

Scopo dello studio: Ricerca sui sistemi sanitari

Classificazione: Studio di coorte

Multi-/Monocentrico: Multicentrico

Sede dello studio: Switzerland

Durata: 01.01.2019 - 31.12.2020

Attivo/inattivo: Inattivo

Reclutamento: Non sono state ricercate ulteriori sedi di studio

Proprietario: Interverband für Rettungswesen IVR-IAS

Commenti:

Contatto: Roman Burkart

Dateien:

ID: 36195

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